Kulthanan Kanokvalai, Jiamton Sukhum, Omcharoen Viboon, Linpiyawan Rumpa, Ruangpeerakul Jaratsak, Sivayathorn Apichati
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand.
Int J Dermatol. 2002 Jul;41(7):417-22. doi: 10.1046/j.1365-4362.2002.01529.x.
There have been reports concerning an association between human immunodeficiency virus (HIV) infection and autoimmune and rheumatic diseases.
The purpose of this study was to examine autoimmune and rheumatic manifestations in HIV-infected patients and their correlation with antinuclear antibody (ANA) tests.
The clinical and laboratory results of HIV-infected patients attending the Department of Dermatology, Siriraj Hospital, Bangkok, Thailand, from February 1999 to January 2000, were analyzed. Laboratory studies included serum CD4 lymphocyte count and ANA tests.
Sixty-two patients were enrolled prospectively in the study. Myalgia was the most common clinical presentation (50%). Others included photosensitivity (on history) (39%), arthralgia (26%), vasculitis (18%), sicca complex (10%), arthritis (7%), and Reiter's syndrome (2%). A history of hair loss was given by 23% of patients. A positive ANA test was detected in 3%. No cases of systemic lupus erythematosus, scleroderma, or dermatomyositis were seen.
Autoimmune and rheumatic manifestations were not uncommonly detected in patients with HIV infection. HIV infection may sometimes mimic systemic lupus erythematosus clinically.
已有关于人类免疫缺陷病毒（HIV）感染与自身免疫性及风湿性疾病之间关联的报道。
本研究旨在检查HIV感染患者的自身免疫性和风湿性表现及其与抗核抗体（ANA）检测的相关性。
分析了1999年2月至2000年1月在泰国曼谷诗里拉吉医院皮肤科就诊的HIV感染患者的临床和实验室结果。实验室检查包括血清CD4淋巴细胞计数和ANA检测。
62例患者前瞻性纳入本研究。肌痛是最常见的临床表现（50%）。其他包括光敏性（病史）（39%）、关节痛（26%）、血管炎（18%）、干燥综合征（10%）、关节炎（7%）和赖特综合征（2%）。23%的患者有脱发史。3%的患者ANA检测呈阳性。未发现系统性红斑狼疮、硬皮病或皮肌炎病例。
在HIV感染患者中，自身免疫性和风湿性表现并不罕见。HIV感染有时在临床上可能类似系统性红斑狼疮。
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