Soto María Elena, Hernández-Becerril Nidia, Perez-Chiney Ada Claudia, Hernández-Rizo Alfredo, Telich-Tarriba José Eduardo, Juárez-Orozco Luis Eduardo, Melendez Gabriela, Bojalil Rafael
Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Universidad Panamericana School of Medicine, Mexico City, Mexico.
Results Immunol. 2013 Nov 9;5:13-22. doi: 10.1016/j.rinim.2013.10.003. eCollection 2015.
Determination of antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) is usually the initial test for the diagnosis of systemic rheumatic diseases (SRD). Assigning predictive values to positive and negative results of the test is vital because lack of knowledge about ANAs and their usefulness in classification criteria of SRD leads to inappropriate use.
Retrospective study, ANA tests requested by different specialties, correlation to patients' final diagnosis.
The prevalence of autoimmune disease was relatively low in our population yielding a low PPV and a high NPV for the ANA test. 40% of the patients had no clinical criteria applied prior to test. Coexistence of two or more autoimmune disorders affects prevalence and predictive values.
Application of the test after careful evaluation for clinical criteria remarkably improves the positive likelihood ratio for the diagnosis.
通过间接免疫荧光法（IIF）检测抗核抗体（ANA）通常是诊断系统性风湿性疾病（SRD）的初始检查。确定该检测阳性和阴性结果的预测价值至关重要，因为对ANA及其在SRD分类标准中的作用缺乏了解会导致检测使用不当。
回顾性研究，不同专科要求进行的ANA检测，与患者最终诊断的相关性。
我们研究人群中自身免疫性疾病的患病率相对较低，导致ANA检测的阳性预测值较低而阴性预测值较高。40%的患者在检测前未应用临床标准。两种或更多种自身免疫性疾病并存会影响患病率和预测值。
在仔细评估临床标准后应用该检测可显著提高诊断的阳性似然比。
