遗传密码：引入吡咯赖氨酸。

Genetic code: introducing pyrrolysine.

作者信息

Ibba Michael, Söll Dieter

机构信息

Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus 43210-1292, USA.

出版信息

Curr Biol. 2002 Jul 9;12(13):R464-6. doi: 10.1016/s0960-9822(02)00947-8.

DOI:10.1016/s0960-9822(02)00947-8

PMID:12121639

Abstract

Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG. Initial studies suggest that pyrrolysine may be co-translationally inserted during protein synthesis, probably by a mechanism analogous to that operating during selenocysteine incorporation.

摘要

巴氏甲烷八叠球菌的单甲胺甲基转移酶含有一种由终止密码子UAG编码的新型氨基酸——吡咯赖氨酸。初步研究表明，吡咯赖氨酸可能在蛋白质合成过程中通过共翻译的方式插入，其机制可能类似于硒代半胱氨酸掺入过程中所起作用的机制。