西班牙北部人群中强直性脊柱炎及相关脊柱关节病患者 HLA - B27 等位基因的高度变异性。
High variability of HLA-B27 alleles in ankylosing spondylitis and related spondyloarthropathies in the population of northern Spain.
作者信息
Gonzalez Segundo, Garcia-Fernandez Sonia, Martinez-Borra Jesus, Blanco-Gelaz Miguel Angel, Rodrigo Luis, Sanchez del Río Jose, López-Vazquez Antonio, Torre-Alonso Juan Carlos, López-Larrea Carlos
机构信息
Functional Biology Department (S.G.), University of Oviedo, Oviedo, Spain.
出版信息
Hum Immunol. 2002 Aug;63(8):673-6. doi: 10.1016/s0198-8859(02)00404-4.
The distribution of B27 alleles (B2701-23) was characterized by PCR-SSP in ankylosing spondylitis and related spondyloarthropathies (SpA) in a sample of B27 positive patients from northern Spain. Six B27 alleles were identified: B2705,02,03,07,08 and B2713. B2705 and 02 were the most common alleles in the SpA studied: ankylosing spondylitis (AS) (n = 89), reactive arthritis (ReA) (n = 11), psoriatic arthritis (PsA) (n = 29), and inflammatory bowel disease (IBD) (n = 21). B2707 and B2708 were found in PsA patients and B2703 in one patient with IBD. B2713 was identified in a healthy control family. B*2713 has not been reported to be represented in either ethnic group. Thus, this population shows higher levels of B27 diversity than other Caucasian groups.
采用聚合酶链反应-序列特异性引物法（PCR-SSP）对来自西班牙北部的一组B27阳性患者样本进行检测，以明确强直性脊柱炎及相关脊柱关节病（SpA）中B27等位基因（B2701-23）的分布情况。共鉴定出6种B27等位基因：B2705、02、03、07、08和B2713。B2705和02是所研究的脊柱关节病中最常见的等位基因，这些疾病包括强直性脊柱炎（AS）（n = 89）、反应性关节炎（ReA）（n = 11）、银屑病关节炎（PsA）（n = 29）和炎性肠病（IBD）（n = 21）。在银屑病关节炎患者中发现了B2707和B2708，在1例炎性肠病患者中发现了B2703。在一个健康对照家族中鉴定出了B2713。尚未有报道称B*2713在任何一个种族群体中出现过。因此，该人群中B27的多样性水平高于其他高加索人群。
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