楚科奇原住民群体中的HLA - B27亚型。

HLA-B27 subtypes among the Chukotka Native groups.

作者信息

Krylov M Y, Reveille J D, Alexeeva L I, Erdesz S, Arnett F C, Benevolenskaya L I

机构信息

Department of Epidemiology and Genetics of Rheumatic Diseases, Institute of Rheumatology of RAMS, Moscow, Russia.

出版信息

Arch Immunol Ther Exp (Warsz). 1995;43(2):135-8.

PMID:8744728

Abstract

The purpose of this study was to assess the relative frequency of the known HLA-B27 subtypes in HLA-B27 positive Chukotka natives, which have higher frequencies of HLA-B27 (to 40%) and spondyloarthropathies (to 2%) than the Russian Caucasian population. Using oligotyping of the polymerase-chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-B27 positive individuals were successfully typed. All had HLA-B2705, including 4 patients with Reiter's syndrome and 5 with ankylosing spondyloarthritis, except one Eskimo who had HLA-B2702. None had HLA-B*2704, a frequent subtype in Orientals. With respect to HLA-B27 subtypes the indigenous populations from the eastern part of the Chukotka Peninsula are genetically more closely related to Caucasians than to Orientalis.

摘要

本研究的目的是评估楚科奇原住民中已知HLA - B27亚型的相对频率，该群体中HLA - B27（高达40%）和脊柱关节病（高达2%）的频率高于俄罗斯高加索人群。通过对86份来自HLA - B27阳性个体的DNA样本进行聚合酶链反应扩增的HLA - B27基因第二和第三外显子的寡核苷酸分型，所有样本均成功分型。除了一名患有HLA - B2702的爱斯基摩人外，所有患者均为HLA - B2705，其中包括4例赖特综合征患者和5例强直性脊柱炎患者。无人具有HLA - B*2704，这是东方人中常见的亚型。就HLA - B27亚型而言，楚科奇半岛东部的原住民在基因上与高加索人比与东方人更为密切相关。