AcrAB-TolC外排泵导致医院病原体产气肠杆菌产生多重耐药性。
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.
作者信息
Pradel Elizabeth, Pagès Jean-Marie
机构信息
INSERM CJF9606-EA2197, IFR48, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
出版信息
Antimicrob Agents Chemother. 2002 Aug;46(8):2640-3. doi: 10.1128/AAC.46.8.2640-2643.2002.
Abstract
We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.
摘要
我们鉴定了产气肠杆菌中编码AcrA-AcrB-TolC外排泵的基因，并从一株多重耐药菌株构建了acrAB和tolC突变体。这两种衍生物对抗生素的敏感性均高于亲本菌株。序列分析和互补实验表明，该多重耐药菌株是一个acrR突变体。
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