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[老年患者的经皮内镜下胃造口术。在一家老年医院的前瞻性研究]

[Percutaneous endoscopic gastrostomy in elderly patients. A prospective study in a geriatric hospital].

作者信息

Abitbol Vered, Selinger-Leneman Hana, Gallais Yves, Piette François, Bouchon Jean-Pierre, Piera Jean-Bernard, Beinis Jean-Yves, Laurent Mireille, Moulias Robert, Gaudric Marianne

机构信息

Hôpital Charles Foix, 7, avenue de la République, 94205 Ivry-sur-Seine Cedex, France.

出版信息

Gastroenterol Clin Biol. 2002 May;26(5):448-53.

Abstract

OBJECTIVES

The purpose of this work was to search for prognostic factors after percutaneous endoscopic gastrostomy (PEG) for enteral nutrition in geriatric patients by studying complications, nutritional benefits, and impact on quality of life.

METHODS

In this prospective study, 59 elderly patients referred for PEG were followed for 1 year or until tube removal or death. Complications, tolerance to enteral nutrition, nutritional status, infection, bedsores and quality of life were assessed by a questionnaire at tube insertion, at 1 month and every 3 months. Multivariate analysis was performed to look for factors predictive of early mortality before one month.

RESULTS

Insertion of the PEG tube was always successful. Pneumonia in the week before tube insertion was predictive of early mortality (odds-ratio: 8.77 [1.63-47.2], P=0.01). Thirty-day mortality was 25%, but was never related to PEG tube insertion. During follow up, no local complication was observed and enteral feeding was well tolerated. After 3 months, serum albumin and prealbumin levels increased (P<0.001). There were fewer infections (P<0.001) and bedsores remained unchanged. Quality-of-life scores were not modified. At one year, the PEG tube was removed in 16 patients who resumed normal oral nutrition, and 6 other patients were able to return to their home.

CONCLUSION

In a cohort of aged institutionalized patients, PEG for enteral nutrition was well tolerated and not definitive in more than one-quarter of them. Active lung infection is a risk factor of early mortality.

摘要

目的

本研究旨在通过研究并发症、营养益处及对生活质量的影响,寻找老年患者经皮内镜下胃造口术(PEG)肠内营养后的预后因素。

方法

在这项前瞻性研究中,59例接受PEG的老年患者随访1年,或直至拔管或死亡。在置管时、1个月时及每3个月通过问卷评估并发症、肠内营养耐受性、营养状况、感染、压疮及生活质量。进行多变量分析以寻找1个月内早期死亡的预测因素。

结果

PEG管置入均成功。置管前一周内发生肺炎是早期死亡的预测因素(比值比:8.77[1.63 - 47.2],P = 0.01)。30天死亡率为25%,但与PEG管置入无关。随访期间,未观察到局部并发症,肠内喂养耐受性良好。3个月后,血清白蛋白和前白蛋白水平升高(P < 0.001)。感染减少(P < 0.001),压疮情况未变。生活质量评分未改变。1年后,16例恢复正常经口营养的患者拔除了PEG管,另外6例患者能够回家。

结论

在一组老年住院患者中,PEG肠内营养耐受性良好,超过四分之一的患者并非永久性依赖。活动性肺部感染是早期死亡的危险因素。

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