Savage Clare, McQuitty Christopher, Wang DongFang, Zwischenberger Joseph B
Division of Cardiothoracic Surgery, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0528, USA.
Chest Surg Clin N Am. 2002 May;12(2):251-63. doi: 10.1016/s1052-3359(02)00011-x.
The following techniques appear efficacious in controlling postthoracotomy pain and reducing the amount of systemic opioids consumed: continuous intercostal blockade, paravertebral blockade, and epidural opioids and/or anesthetics. The combination of thoracic epidural opioid and local anesthetic is very effective at relieving postthoracotomy pain, however, considerable experience is required for insertion of the thoracic epidural catheter and postoperative respiratory monitoring. Intercostal and paravertebral catheters can be inserted intraoperatively under direct visualization, to reduce complications of insertion. One-time intraoperative intercostal blockade may effectively reduce postoperative pain in the first day, but is not a practical long-term method for postthoracotomy pain. The effectiveness of interpleural analgesia, even with proper technique, appears inferior to epidural and other regional techniques. We have incorporated the principles outlined in this review into our general thoracic surgery protocol, as detailed in Fig. 1. Every patient is assessed preoperatively for epidural catheter placement. Contraindications include low platelet count (< 100,000), abnormal coagulation profile, medicinal anticoagulation (aspirin and nonsteroidal anti-inflammatories are not contraindications), bony spinal abnormalities, or neurological disorders. The T5/6 interspace is our preferred level, but T10 can work well with an increased dose of bupivacaine. Upon completion of the muscle sparing, minimal-access thoracotomy, we close the wound and perform a percutaneous intercostal nerve block (two ribs above and three below the incision). We then use patient-controlled epidural analgesia, with a basal infusion of bupivacaine and hydromorphone. To supplement inadequate or nonfunctioning epidurals, intravenous patient-controlled opioids are added. When choosing an approach to postthoracotomy pain management, the thoracic surgeon and anesthesiologist must consider the following: (1) the physician's experience, familiarity and personal complication rate with specific techniques; (2) the desired extent of local and systemic pain control; (3) the presence of contraindications to specific analgesic techniques and medications; and (4) availability of appropriate facilities for patient assessment and monitoring postthoracotomy. Refinements in surgical technique including limited or muscle-sparing thoracotomy, video-assisted thoracoscopic surgery (VATS) and robotic surgery may lessen the magnitude of postthoracotomy pain. We encourage all thoracic surgeons to be knowledgeable of available techniques and maintain a protocol to generate a database for periodic assessment of safety and efficacy.
连续肋间阻滞、椎旁阻滞以及硬膜外使用阿片类药物和/或麻醉剂。胸段硬膜外联合使用阿片类药物和局麻药在缓解开胸术后疼痛方面非常有效,然而,插入胸段硬膜外导管及术后呼吸监测需要相当丰富的经验。肋间导管和椎旁导管可在术中直视下插入,以减少插入相关并发症。一次性术中肋间阻滞可有效减轻术后首日疼痛,但并非开胸术后疼痛的实用长期方法。即使技术得当,胸膜间镇痛的效果似乎也逊于硬膜外及其他区域技术。我们已将本综述中概述的原则纳入我们的普通胸外科手术方案,如图1所示。每位患者术前均评估是否适合放置硬膜外导管。禁忌证包括血小板计数低(<100,000)、凝血指标异常、药物抗凝(阿司匹林和非甾体抗炎药并非禁忌)、脊柱骨质异常或神经疾病。T5/6间隙是我们首选的节段,但T10节段在增加布比卡因剂量时效果也很好。在完成保留肌肉的小切口开胸术后,我们关闭伤口并进行经皮肋间神经阻滞(切口上方两根肋骨和下方三根肋骨处)。然后我们使用患者自控硬膜外镇痛,持续输注布比卡因和氢吗啡酮。为补充效果不佳或不起作用的硬膜外镇痛,加用静脉自控阿片类药物。在选择开胸术后疼痛管理方法时,胸外科医生和麻醉医生必须考虑以下几点:(1)医生对特定技术的经验、熟悉程度和个人并发症发生率;(2)局部和全身疼痛控制的预期程度;(3)特定镇痛技术和药物的禁忌证;(4)开胸术后患者评估和监测的适当设施的可用性。包括有限或保留肌肉的开胸术、电视辅助胸腔镜手术(VATS)和机器人手术在内的手术技术改进可能会减轻开胸术后疼痛的程度。我们鼓励所有胸外科医生了解可用技术,并维持一个方案以建立数据库,定期评估安全性和有效性。