Menditto Antonio, Chiodo Ferdinando
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Roma.
Ann Ist Super Sanita. 2002;38(1):77-85.
The use of chemicals warrants many benefits on which modern society is entirely dependent. On the other hand, the lack of reliable information about the impact of the use of chemicals raises increasing concern. In order to guarantee the safety of chemicals it is mandatory to proceed to risk assessment, which in turn consists of hazard evaluation and exposure estimation. These activities are strictly dependent upon the availability of reliable data and information, produced by, e.g., test facilities, test laboratories and clinical laboratories, the specific competence of which has been properly recognised. All this applies in the pre-marketing phase as well as during the use of chemical substances. In this latter phase it is necessary to carry out an appropriate monitoring of environment, food and, in specific situations, human beings (biological monitoring). In the field of chemical safety, standards, legal instruments and operative instruments are nowadays available. These tools make it possible to assess both the quality of data and the competence of the entities involved in the production of the data themselves.
化学品的使用带来了许多益处,现代社会完全依赖于此。另一方面,缺乏关于化学品使用影响的可靠信息引发了越来越多的关注。为了确保化学品的安全,必须进行风险评估,而风险评估又包括危害评估和暴露估计。这些活动严格依赖于可靠数据和信息的可得性,这些数据和信息由例如测试设施、测试实验室和临床实验室提供,其特定能力已得到适当认可。所有这些在化学品上市前阶段以及使用过程中均适用。在后一阶段,有必要对环境、食品以及在特定情况下对人类进行适当监测(生物监测)。在化学安全领域,如今已有标准、法律工具和操作工具。这些工具使得能够评估数据质量以及数据生产所涉实体的能力。