Leme J G, Wilhelm D L
Br J Exp Pathol. 1975 Oct;56(5):402-7.
The vascular permeability response induced in the rat by intracutaneous histamine or serotonin is noticeably influenced by previous adrenalectomy or treatment with corticosterone. Permeability responses were demonstrated by the local exudation of circulating Evans blue at sites of intracutaneous injection of the above permeability factors, the intensity of the responses being assessed by the diameter of the blue lesions as well as by the amount of exuded dye. In adrenalectomized rats maintained for 72-80 h on 0-9% solution of NaCl, the permeability response to histamine was enhanced about 10-fold, that to serotonin about 5-fold. When rats were given subcutaneous corticosterone, 1-0 mg/animal 1 h before testing, the responses to the same 2 permeability factors were decreased about 10-fold and 5-fold respectively. Corticosterone also decreased the enhanced responses in adrenalectomized rats to levels somewhat below those in mock adrenalectomized controls. The results support the proposal from other work that vascular exudation in experimental inflammation is regulated by an anti-inflammatory factor that accumulates in injured tissues and owes its effect to release of corticosteroids.
大鼠皮内注射组胺或血清素所诱导的血管通透性反应，会受到先前肾上腺切除术或皮质酮治疗的显著影响。通过在皮内注射上述通透性因子的部位，循环伊文思蓝的局部渗出证明通透性反应，反应强度通过蓝色病变的直径以及渗出染料的量来评估。在以0.9%氯化钠溶液维持72 - 80小时的肾上腺切除大鼠中，对组胺的通透性反应增强约10倍，对血清素的反应增强约5倍。当在测试前1小时给大鼠皮下注射皮质酮，剂量为1.0毫克/只动物时，对相同两种通透性因子的反应分别降低约10倍和5倍。皮质酮还将肾上腺切除大鼠中增强的反应降低到略低于假肾上腺切除对照大鼠的水平。这些结果支持了其他研究提出的观点，即实验性炎症中的血管渗出受一种抗炎因子调节，该因子在损伤组织中积累，其作用归因于皮质类固醇的释放。
