Aloni B, Shinitzky M, Moses S, Livne A
Br J Haematol. 1975 Sep;31(1):117-23. doi: 10.1111/j.1365-2141.1975.tb00839.x.
Erythrocytes affected by hereditary spherocytosis (HS), obtained from several splenectomized patients, showed a varying degree of elevated osmotic fragility. In order to evaluate a possible role of the erythrocyte membrane lipids in HS, microviscosity of the membrane lipid core was measured by a fluorescence-polarization technique. Intact HS-affected red cells, as well as their ghost membranes and liposomes prepared from their lipid extract, all showed a distinctly higher micro-viscosity than the respective normal control. The increased microviscosity correlated with the severity of HS. The data support the proposition that the defect in HS-affected red cells is associated, at least in part, with alterations in the membrane lipids.
从几名脾切除患者身上获取的受遗传性球形红细胞增多症（HS）影响的红细胞，显示出不同程度的渗透脆性升高。为了评估红细胞膜脂质在HS中可能发挥的作用，通过荧光偏振技术测量了膜脂质核心的微粘度。完整的受HS影响的红细胞，以及它们的空细胞膜和由其脂质提取物制备的脂质体，均显示出比各自的正常对照明显更高的微粘度。微粘度的增加与HS的严重程度相关。这些数据支持这样一种观点，即受HS影响的红细胞中的缺陷至少部分与膜脂质的改变有关。
