Johnsson R, Saris N E
Clin Chim Acta. 1981 Aug 10;114(2-3):263-8. doi: 10.1016/0009-8981(81)90399-5.
Determinations were made of the concentrations of cholesterol, triglycerides and phospholipids in plasma from 18 patients with hereditary or congenital spherocytosis (HS). The plasma cholesterol and phospholipid levels of these patients were significantly depressed, whereas the triglyceride levels were normal. Phospholipids from plasma and red cell ghosts were analysed by thin-layer chromatography. The relative amount of phosphatidylethanolamine was decreased in both plasma and red cell membranes from HS patients, whereas significant alterations were not observed in the relative amounts of the other major phospholipid classes. These data show that in HS the abnormal lipid metabolism is not confined only to the red cell; it also affects the plasma lipids and therefore probably other cells as well.
对18例遗传性或先天性球形红细胞增多症（HS）患者的血浆胆固醇、甘油三酯和磷脂浓度进行了测定。这些患者的血浆胆固醇和磷脂水平显著降低，而甘油三酯水平正常。采用薄层色谱法分析血浆和红细胞影中的磷脂。HS患者血浆和红细胞膜中磷脂酰乙醇胺的相对含量均降低，而其他主要磷脂类别的相对含量未观察到显著变化。这些数据表明，在HS中，异常的脂质代谢不仅局限于红细胞；它还影响血浆脂质，因此可能也影响其他细胞。
