[多肽链体内合成的动力学；翻译抑制剂的作用]

[Kinetics of the in vivo synthesis of the polypeptide chain; the effect of translation inhibitors].

作者信息

Leĭtin V L, Lerman M I

出版信息

Biokhimiia. 1975 Sep-Oct;40(5):1060-70.

Abstract

Effects of aurinetricarbonic acid and cycloheximide on kinetics of polypeptide chain synthesis and polyribosome protile in mouse liver cell in vivo are studied. Both compounds are found to decrease the absolute rate of protein synthesis and to increase the time of polypeptide synthesis. Cycloheximide changed the ratio of translating and non-translating ribosomes and different in size polyribosome types. Aurinetricarbonic acid exerts no effect on polyribosome profile. Effects of cycloheximide and aurinetricarbonic acid on kinetic parameters of translation and a mechanism of action of these compounds are studied.

摘要

研究了金精三羧酸和放线菌酮对小鼠肝细胞体内多肽链合成动力学和多核糖体图谱的影响。发现这两种化合物均降低蛋白质合成的绝对速率并延长多肽合成时间。放线菌酮改变了正在翻译和未翻译核糖体的比例以及不同大小多核糖体类型。金精三羧酸对多核糖体图谱无影响。研究了放线菌酮和金精三羧酸对翻译动力学参数的影响以及这些化合物的作用机制。

相似文献

1

[Kinetics of the in vivo synthesis of the polypeptide chain; the effect of translation inhibitors].[多肽链体内合成的动力学；翻译抑制剂的作用]

Biokhimiia. 1975 Sep-Oct;40(5):1060-70.

2

[The interaction between newly-formed mRNA and ribosomal particles during retarded translation].[延迟翻译过程中新合成的mRNA与核糖体颗粒之间的相互作用]

Mol Biol (Mosk). 1975 Nov-Dec;9(6):845-55.

3

[Determination of the time of polypeptide chain synthesis in animal experiments].

Biokhimiia. 1975 May-Jun;40(3):513-20.

4

The effect of some antibiotics on protein synthesis activity of in vitro reconstituted rough membrane from rat liver.某些抗生素对大鼠肝脏体外重建粗面内质网蛋白质合成活性的影响。

FEBS Lett. 1975 Jun 15;54(2):126-9. doi: 10.1016/0014-5793(75)80058-5.

5

Aurintriboxylic acid as both a stimulator and an inhibitor of cell-free protein synthesis by rat heart polyribosomes.金精三羧酸作为大鼠心脏多核糖体无细胞蛋白质合成的刺激剂和抑制剂。

Biochem Biophys Res Commun. 1982 Jan 29;104(2):750-7. doi: 10.1016/0006-291x(82)90701-x.

6

Inhibition of translation in reticulocyte lysate by the mycotoxin patulin.

FEBS Lett. 1978 Nov 15;95(2):252-6. doi: 10.1016/0014-5793(78)81005-9.

7

Characterisation of protein synthesis in cell-free extracts from different mammalian cells by their sensitivity to inhibitors of polypeptide-chain initiation.通过不同哺乳动物细胞无细胞提取物对多肽链起始抑制剂的敏感性来表征蛋白质合成。

Hoppe Seylers Z Physiol Chem. 1979 Aug;360(8):1099-111. doi: 10.1515/bchm2.1979.360.2.1099.

8

Comparison of the activities for polypeptide synthesis of polysomes prepared with different detergents from normal and regenerating rat liver.用不同去污剂从正常大鼠肝脏和再生大鼠肝脏制备的多核糖体的多肽合成活性比较。

J Biochem. 1975 Jun;77(6):1255-9.

9

[Polysomal apparatus as a reflection of function interactions between translation and transcription processes during protein synthesis inhibited by cycloheximide].[多核糖体装置作为环己酰亚胺抑制蛋白质合成过程中转录与翻译功能相互作用的反映]

Biokhimiia. 1977 Dec;42(12):2149-59.

10

The in vivo effect of dimethyl sulphoxide (DMSO) on protein synthesis and the polyribosome profile in Paramecium.

J Cell Physiol. 1977 Feb;90(2):169-77. doi: 10.1002/jcp.1040900204.

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