[多肽链体内合成的动力学；翻译抑制剂的作用]
[Kinetics of the in vivo synthesis of the polypeptide chain; the effect of translation inhibitors].
作者信息
Leĭtin V L, Lerman M I
出版信息
Biokhimiia. 1975 Sep-Oct;40(5):1060-70.
Effects of aurinetricarbonic acid and cycloheximide on kinetics of polypeptide chain synthesis and polyribosome protile in mouse liver cell in vivo are studied. Both compounds are found to decrease the absolute rate of protein synthesis and to increase the time of polypeptide synthesis. Cycloheximide changed the ratio of translating and non-translating ribosomes and different in size polyribosome types. Aurinetricarbonic acid exerts no effect on polyribosome profile. Effects of cycloheximide and aurinetricarbonic acid on kinetic parameters of translation and a mechanism of action of these compounds are studied.
研究了金精三羧酸和放线菌酮对小鼠肝细胞体内多肽链合成动力学和多核糖体图谱的影响。发现这两种化合物均降低蛋白质合成的绝对速率并延长多肽合成时间。放线菌酮改变了正在翻译和未翻译核糖体的比例以及不同大小多核糖体类型。金精三羧酸对多核糖体图谱无影响。研究了放线菌酮和金精三羧酸对翻译动力学参数的影响以及这些化合物的作用机制。
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