[大鼠肝脏细胞核组蛋白乙酰化的年龄相关特性]
[Age-related peculiarities of acetylation of rat liver nuclear histones].
作者信息
Klimenko A I, Malyshev A B, Nikitin V N, Simirenko L L
出版信息
Biokhimiia. 1975 Sep-Oct;40(5):1087-90.
PMID:1212446
Abstract
The intensity of acetylation of different histone fraction is found to change in postnatal ontogenesis of albino rats. The intensity of acetylation of lisine-rich histone (F1) was maximal in 3-and 12-month old animals. The label incorporation into F3 (arginine-rich) histones considerably decreased in the time interval between 1st and 3d months while its incorporation increased into F2 histones furing all the period of postnatal development studied.
摘要
研究发现，白化大鼠出生后的个体发育过程中，不同组蛋白组分的乙酰化强度会发生变化。富含赖氨酸的组蛋白（F1）的乙酰化强度在3个月和12个月大的动物中最高。在第1个月到第3个月的时间间隔内，标记物掺入F3（富含精氨酸）组蛋白的量显著减少，而在整个出生后发育研究期间，其掺入F2组蛋白的量增加。
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