Kravchenko L S, Oksman A Ia, Tereshin I M
Biokhimiia. 1975 Nov-Dec;40(6):1185-92.
Effects of amphotericine B and nistatine on plasmatic membranes of dog kidney are studied. Intravenous injection of antibiotics resulted in the change of the chemical composition of plasmatic membranes: the content of proteins, lipids and RNA. The composition of membrane proteins and the quantitative ratio of separate fatty acids in lipids of plasmatic membranes also changed in the presence of amphotericine B and nistatine. It is suggested on the basis of the data obtained that the mechanism of action of polyene antibiotics in dog kidney cells is connected with the damage of membrane structures.
研究了两性霉素B和制霉菌素对犬肾质膜的影响。静脉注射抗生素导致质膜化学成分发生变化：蛋白质、脂质和RNA的含量。在两性霉素B和制霉菌素存在的情况下，质膜的膜蛋白组成以及脂质中各脂肪酸的定量比例也发生了变化。根据所获得的数据表明，多烯抗生素在犬肾细胞中的作用机制与膜结构的损伤有关。
