与美国白人相比，中国北京老年人髋骨关节炎患病率极低：北京骨关节炎研究

Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study.

作者信息

Nevitt Michael C, Xu Ling, Zhang Yuqing, Lui Li-Yung, Yu Wei, Lane Nancy E, Qin Mingwei, Hochberg Marc C, Cummings Steven R, Felson David T

机构信息

Prevention Sciences, University of California, San Francisco, 94105, USA.

出版信息

Arthritis Rheum. 2002 Jul;46(7):1773-9. doi: 10.1002/art.10332.

DOI:10.1002/art.10332

PMID:12124860

Abstract

OBJECTIVE

To compare the prevalence of osteoarthritis (OA) of the hip among elderly persons in China and the US.

METHODS

We recruited a population-based sample of 1,506 persons (82% of those enumerated) ages > or = 60 years living in Beijing, China. Subjects answered questions about joint symptoms and underwent radiography of the pelvis. Radiographs of the Beijing subjects were intermingled with hip radiographs of white women ages > or = 65 years from the Study of Osteoporotic Fractures (SOF) and white men and women ages 60-74 years from the First National Health and Nutrition Examination Survey (NHANES-I) and were then interpreted. Radiographic hip OA was defined as the presence of 1 of the following 3 findings in either hip: minimum joint space of < or = 1.5 mm, definite osteophytes and joint space narrowing, or > or = 3 radiographic features of OA. Symptomatic hip OA was defined as both radiographic OA and hip pain.

RESULTS

The crude prevalence of radiographic hip OA in Chinese ages 60-89 years was 0.9% in women and 1.1% in men; it did not increase with age. Chinese women had a lower age-standardized prevalence of radiographic hip OA compared with white women in the SOF (age-standardized prevalence ratio 0.07) and the NHANES-I (prevalence ratio 0.22). Chinese men had a lower prevalence of radiographic hip OA compared with white men of the same age in the NHANES-I (prevalence ratio 0.19). There were no cases of symptomatic hip OA in the Chinese men and only 1 case in the Chinese women; 35 cases were expected in both sexes.

CONCLUSION

This is the first population-based study of hip OA in China to use standardized radiographic methods and definitions. We found that hip OA was 80-90% less frequent than in white persons in the US. Identification of the genetic and environmental factors that underlie these differences may help elucidate the etiology and prevention of hip OA.

摘要

目的

比较中国和美国老年人髋关节骨关节炎（OA）的患病率。

方法

我们选取了居住在中国北京的1506名年龄≥60岁的人群作为基于人群的样本（占应调查人数的82%）。受试者回答有关关节症状的问题，并接受骨盆X光检查。北京受试者的X光片与来自骨质疏松性骨折研究（SOF）的年龄≥65岁白人女性以及来自第一次全国健康和营养检查调查（NHANES-I）的年龄在60 - 74岁的白人男性和女性的髋关节X光片混合，然后进行解读。放射学髋关节OA定义为任一髋关节出现以下3种情况之一：最小关节间隙≤1.5毫米、明确的骨赘和关节间隙变窄，或≥3个OA的放射学特征。有症状的髋关节OA定义为既有放射学OA又有髋关节疼痛。

结果

中国60 - 89岁人群中，放射学髋关节OA的粗患病率女性为0.9%，男性为1.1%；患病率未随年龄增加。与SOF中的白人女性（年龄标准化患病率比0.07）和NHANES-I中的白人女性（患病率比0.22）相比，中国女性放射学髋关节OA的年龄标准化患病率较低。与NHANES-I中同年龄的白人男性相比，中国男性放射学髋关节OA的患病率较低（患病率比0.19）。中国男性中没有有症状的髋关节OA病例，中国女性中仅有1例；两性预计应有35例。