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孕期雄激素过多对大鼠孕期及出生后发育的影响

[Effect of prenatal hyperandrogenism during pregnancy and on postnatal development of rats].

作者信息

Klimova O P

机构信息

V. Danilevsky Institute of Endocrine Pathology Problems, Kharkiv.

出版信息

Fiziol Zh (1994). 2002;48(3):66-71.

Abstract

Hyperandrogenia was modelled in the female rats within the whole term of pregnancy by means of testosterone or dihydrotestosterone. Both androgens have been established to induce significant prenatal mortality and high percentage of mortinatus and postnatal mortality of progeny. Hyperandrogenization influenced negatively the sexual development and reproductive function of the female progeny versus the male one.

摘要

在整个孕期内,通过睾酮或双氢睾酮在雌性大鼠中模拟高雄激素血症。已证实这两种雄激素都会导致显著的产前死亡率以及子代中高比例的死胎和产后死亡率。与雄性子代相比,高雄激素化对雌性子代的性发育和生殖功能产生了负面影响。

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