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[吡拉西坦对大鼠生殖功能及其子代性发育的影响]

[Effect of piracetam on rat reproductive function and the sexual development of their progeny].

作者信息

Terekhina A I, Kruglova O N

出版信息

Farmakol Toksikol. 1987 May-Jun;50(3):69-70.

PMID:3609283
Abstract

Administration of piracetam to infantile rats in a daily dose of 100 mg/kg for 10 days caused acceleration of sexual maturation of females and a slight delay of maturation of males. Antenatal administration of the same dose of piracetam exerted a depressive action on the development of the organs of the reproductive system in males from the offspring with a simultaneous increase in the pituitary gonadotropic activity.

摘要

以每日100毫克/千克的剂量给幼鼠注射吡拉西坦,持续10天,会导致雌性幼鼠性成熟加速,雄性幼鼠成熟稍有延迟。产前给予相同剂量的吡拉西坦,对后代雄性生殖系统器官的发育产生抑制作用,同时垂体促性腺活性增加。

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