Sonawane B R, Yaffe S J
Biol Res Pregnancy Perinatol. 1983;4(2):48-55.
This article reviews the delayed effects of anticonvulsants (phenobarbital, phenytoin, and valproate) administered in utero upon the reproductive function in the offspring. Experimental data from the authors' laboratories are discussed in light of this context. Furthermore, comments are made emphasizing the gaps in our knowledge concerning the problem of drug exposure during pregnancy and the complex nature of drug effects upon the reproductive system.
本文综述了子宫内给予抗惊厥药物(苯巴比妥、苯妥英和丙戊酸盐)对后代生殖功能的延迟影响。结合这一背景讨论了作者实验室的实验数据。此外,还强调了我们在孕期药物暴露问题以及药物对生殖系统影响的复杂性方面的知识空白。