Effects of orlistat on fat-soluble vitamins in obese adolescents.

STUDY OBJECTIVES

To determine whether orlistat causes fat-soluble vitamin deficiencies in African-American and Caucasian adolescents.

DESIGN

Prospective, open-label pilot study.

SETTING

Warren Grant Magnuson Clinical Center of the National Institutes of Health.

PATIENTS

Seventeen adolescents with body mass indexes above the 95th percentile for age, race, and gender who also had at least one obesity-related comorbid condition.

INTERVENTION

Subjects received orlistat 120 mg 3 times/day and a daily multivitamin supplement containing vitamin A 5000 IU, vitamin D 400 IU, vitamin E 300 IU, and vitamin K 25 microg.

MEASUREMENTS AND MAIN RESULTS

During 3-6 months of orlistat treatment, acute absorption of retinol (vitamin A) was not significantly altered, but absorption of alpha-tocopherol (vitamin E) was significantly reduced compared with baseline levels (p<0.001). Serum levels of vitamins A and E did not change significantly; however, there was a nonsignificant decrease in vitamin K. Mean vitamin D levels were significantly reduced compared with baseline (p<0.02) after 1 month of orlistat, despite multivitamin supplementation.

CONCLUSION

It may be prudent to monitor vitamin D concentrations in adolescents who take orlistat, even when a multivitamin is prescribed.