Adamczewska Daria, Słowikowska-Hilczer Jolanta, Walczak-Jędrzejowska Renata
Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, 92-213 Lodz, Poland.
Biomedicines. 2022 Dec 29;11(1):90. doi: 10.3390/biomedicines11010090.
Previous systematic reviews of the effects of vitamin D on the components of male fertility have been inconclusive. This article systematically reviews the latest research to examine the relationship between vitamin D, semen quality parameters, and sex hormones production.
MEDLINE, Cochrane, and Web of Science databases were searched using the appropriate keywords.
Observational studies indicate significant correlation between vitamin D levels and sperm parameters, with a particular emphasis on sperm motility, and partially suggest a relationship between higher serum testosterone and vitamin D levels. Additionally, interventional studies confirmed that vitamin D supplementation has a positive effect on sperm motility, especially progressive. However, most randomized clinical trials indicate that vitamin D treatment does not have any significant effect on testosterone or other hormone levels.
Although our findings add to the discussion regarding the effect of vitamin D on male fertility, there is still no solid evidence to support the use of vitamin D supplementation to improve the outcomes of patients with impaired sperm parameters and hormonal disorders. Additional dedicated clinical studies are needed to clarify the relationship between vitamin D and male fertility, along with its components.
先前关于维生素D对男性生育各组成部分影响的系统评价尚无定论。本文系统回顾最新研究，以探讨维生素D、精液质量参数和性激素产生之间的关系。
使用适当的关键词检索MEDLINE、Cochrane和科学网数据库。
观察性研究表明维生素D水平与精子参数之间存在显著相关性，尤其着重于精子活力，并且部分研究提示血清睾酮水平较高与维生素D水平之间存在关联。此外，干预性研究证实补充维生素D对精子活力有积极作用，尤其是对进行性精子活力。然而，大多数随机临床试验表明维生素D治疗对睾酮或其他激素水平没有任何显著影响。
尽管我们的研究结果为关于维生素D对男性生育影响的讨论增添了内容，但仍没有确凿证据支持使用补充维生素D来改善精子参数受损和激素紊乱患者的结局。需要更多专门的临床研究来阐明维生素D与男性生育及其各组成部分之间的关系。
