Dagogo-Jack Samuel
Division of Endocrinology, Diabetes & Metabolism, University of Tennessee College of Medicine, Memphis 38163, USA.
J Natl Med Assoc. 2002 Jul;94(7):549-60.
Diabetes is the leading cause of blindness, end-stage renal failure, non-traumatic limb amputations, and cardiovascular morbidity and mortality. The vast majority of patients with diabetes receive routine care from primary care providers who are not endocrinologists. Primary care providers, including internists, family practice physicians, and physician extenders with advanced skills, face the important task of implementing standards of care recommendations for persons with diabetes. These recommendations draw upon an emerging body of compelling evidence regarding the prevention and management diabetes and its complications. The challenge of diabetes must be tackled on three fronts: Primary prevention, secondary prevention (of diabetes complications), and tertiary prevention (of morbidity and mortality from established complications). There is now abundant evidence that type 2 diabetes, which accounts for greater than 90% of diabetes world-wide, is preventable. Moreover, the complications of diabetes are preventable by a policy of tight glycemic control and comprehensive risk reduction. Even after complications have set in, intensive glucose control dramatically reduces the risk of progression of complications. The challenge, therefore, is the identification of strategies that enable translation of existing scientific data to pragmatic benefits. This article proposes 10 strategies for preventing or reducing diabetes-related morbidity and mortality at the primary care level. These strategies include provider education; patient empowerment through promotion of lifestyle and self-care practices; surveillance for microvascular complications; cardiovascular risk reduction; efficient use of medications; goal setting; and stratification of patients and triaging of those with poor glycemic control for more intensive management.
糖尿病是导致失明、终末期肾衰竭、非创伤性肢体截肢以及心血管疾病发病和死亡的主要原因。绝大多数糖尿病患者接受的是初级保健提供者的常规护理,这些提供者并非内分泌科医生。初级保健提供者,包括内科医生、家庭医生以及具备高级技能的医生助理,面临着为糖尿病患者实施护理标准建议这一重要任务。这些建议借鉴了关于糖尿病及其并发症预防和管理的大量新出现的有力证据。应对糖尿病挑战必须从三个方面着手:一级预防、二级预防(糖尿病并发症的预防)以及三级预防(已确诊并发症导致的发病和死亡的预防)。现在有充分证据表明,占全球糖尿病患者90%以上的2型糖尿病是可预防的。此外,通过严格的血糖控制和全面降低风险的政策,糖尿病并发症也是可预防的。即使在并发症已经出现之后,强化血糖控制也能显著降低并发症进展的风险。因此,挑战在于确定能够将现有科学数据转化为实际益处的策略。本文提出了10项在初级保健层面预防或降低糖尿病相关发病和死亡的策略。这些策略包括提供者教育;通过促进生活方式和自我护理实践增强患者能力;监测微血管并发症;降低心血管风险;有效使用药物;设定目标;以及对患者进行分层,并对血糖控制不佳的患者进行分类以便进行更强化的管理。