Skalkos Sophie, Moschonis George, Thomas Colleen J, McMillan Joanna, Kouris-Blazos Antigone
Department of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Victoria 3086, Australia.
Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Victoria 3086, Australia.
Nutrients. 2020 Apr 27;12(5):1239. doi: 10.3390/nu12051239.
Hospital biscuit snacks offered to Type 2 Diabetes Mellitus (T2DM) patients may adversely affect glycaemic control. This study investigated the effect of lupin mid-meal biscuit snacks, compared to spelt or standard hospital biscuits, on interstitial glucose levels in post-operative T2DM inpatients. In a pilot cross-over pragmatic study, 20 patients (74 ± 12 years) consumed, in order, lupin biscuits (20% lupin), wholemeal spelt and standard plain sweet biscuits as mid-meal snacks (2 biscuits each for morning and afternoon tea) on three consecutive days. Continuous glucose monitoring, appetite perceptions and bowel motions were recorded. Glucose levels were not significantly different in the first 90 min after mid-meal biscuit consumption at morning and afternoon tea, irrespective of type. However, after consuming the lupin biscuits only, glucose levels were significantly ( < 0.001) reduced 90 min postprandially after dinner, indicating a potential second-meal effect. Patients also reported improved satiety after lupin biscuit consumption on day 1, compared to days 2 and 3 ( = 0.018). These findings suggest that lupin-enriched biscuits may improve both glycaemic control and satiety in hospitalised T2DM patients, potentially contributing to reduced length of stay. Larger controlled studies are warranted to confirm these findings and inform potential revision of hospital menu standards for T2DM patients.
提供给2型糖尿病（T2DM）患者的医院饼干零食可能会对血糖控制产生不利影响。本研究调查了与斯佩尔特小麦饼干或标准医院饼干相比，羽扇豆餐中饼干零食对术后T2DM住院患者间质葡萄糖水平的影响。在一项试点交叉实用性研究中，20名患者（74±12岁）连续三天依次食用羽扇豆饼干（20%羽扇豆）、全麦斯佩尔特小麦饼干和标准普通甜饼干作为餐中零食（上午茶和下午茶各2块饼干）。记录连续血糖监测、食欲感知和排便情况。无论饼干类型如何，上午茶和下午茶食用餐中饼干后的前90分钟内，葡萄糖水平无显著差异。然而，仅食用羽扇豆饼干后，晚餐后90分钟的血糖水平显著降低（<0.001），表明存在潜在的第二餐效应。与第2天和第3天相比，患者在第1天食用羽扇豆饼干后也报告饱腹感有所改善（=0.018）。这些发现表明，富含羽扇豆的饼干可能会改善住院T2DM患者的血糖控制和饱腹感，有可能缩短住院时间。有必要进行更大规模的对照研究来证实这些发现，并为修订T2DM患者的医院菜单标准提供依据。
