Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.
作者信息
Motoyama Tomoko, Yabunaka Hiromi, Miyoshi Hideto
机构信息
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, 606-8502, Kyoto, Japan.
出版信息
Bioorg Med Chem Lett. 2002 Aug 19;12(16):2089-92. doi: 10.1016/s0960-894x(02)00374-8.
Abstract
To elucidate the role of the hydrophobic alkyl tail of acetogenins in the inhibitory action, we synthesized an acetogenin derivative possessing the shortest tail (i.e., methyl group) and examined its inhibitory activity against bovine heart mitochondrial complex I. Our results indicated that the alkyl tail, which is one of the common structural features of natural acetogenins, is not an essential structural factor required for the potent inhibition.
摘要
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