Kojima Naoto, Tanaka Tetsuaki
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan.
Molecules. 2009 Sep 17;14(9):3621-61. doi: 10.3390/molecules14093621.
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an alpha,beta-unsaturated gamma-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.
大多数番荔枝科杀精素的特征是在C32/34脂肪酸的中心有1至3个四氢呋喃环，环上带有1或2个位于侧翼的羟基，且末端羧酸与一个2-丙醇单元结合形成α,β-不饱和γ-内酯。由于天然杀精素具有吸引人的生物活性和独特的结构特征，许多研究都涉及了它们的性质和合成，同时也描述了一些类似物。这篇综述涵盖了杀精素类似物的设计、合成及生物学评价。
