恶唑烷酮类新型抗菌剂的合成与生物学评价
The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
作者信息
Sciotti Richard J, Pliushchev Marina, Wiedeman Paul E, Balli Darlene, Flamm Robert, Nilius Angela M, Marsh Kennan, Stolarik DeAnne, Jolly Robert, Ulrich Roger, Djuric Stevan W
机构信息
Abbott Laboratories, Infectious Disease Research, Department 47N, Abbott Park, IL 60064, USA.
出版信息
Bioorg Med Chem Lett. 2002 Aug 19;12(16):2121-3. doi: 10.1016/s0960-894x(02)00352-9.
Abstract
A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
摘要
公开了一系列新型的恶唑烷酮类抗菌剂。相对于先前描述的类似物，这些化合物的特征在于具有“卤代芪衍生的”药效基团，并且与利奈唑胺相比，对关键革兰氏阳性病原体表现出增强的抗菌活性。
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