Shestakov S V, Fatenkov V N, Movshovich B L, Naddachina T A, Rusakov V M
Cor Vasa. 1975;17(4):254-61.
In 328 patients with myocardial infarction, changes were followed occurring in the levels of haptoglobin (Hp) and chloride-soluble mucoprotein (CMP), heterogeneity of mucoprotein, and titres of anticardial antibodies. From the 2nd-3rd days after infarction, the levels of Hp, CMP, and 3rd and 4th mucoprotein fractions increased and remained elevated for 4 weeks; then the levels gradually sank, and normalized in the 7th-8th weeks after infarction. The anticardial antibody titres remained high from the 3rd to the 6th weeks. In 37 patients who died, the clinico-biochemical, immunobiological, and morphological findings were compared. It was found that assessments of the Hp and CMP levels as well as of mucoprotein heterogeneity make it possible to appraise the intensity of inflammatory reaction in myocardial necroses and thus facilitate the choice of differentiated antiinflammatory treatment of patients with myocardial infarction.
对328例心肌梗死患者，观察了触珠蛋白（Hp）和氯溶性粘蛋白（CMP）水平、粘蛋白异质性及抗心肌抗体滴度的变化。梗死发生后第2至3天起，Hp、CMP以及第3和第4粘蛋白组分水平升高，并持续4周；之后逐渐下降，在梗死后第7至8周恢复正常。抗心肌抗体滴度在第3至6周一直维持在较高水平。对37例死亡患者的临床生化、免疫生物学及形态学检查结果进行了比较。发现对Hp和CMP水平以及粘蛋白异质性的评估有助于评估心肌坏死中炎症反应的强度，从而便于为心肌梗死患者选择有针对性的抗炎治疗。
