Movshovich B L, Naddachina T A
Kardiologiia. 1977 Jan;17(1):108-14.
To develop intravital criteria of the reperative processes following myocardial infarction, clinical, biochemical and morphological parallels were traced in 62 patients dying of myocardial infarction after different periods following the onset of the disease. It was demonstrated that a set of laboratory techniques (examinations of haptoglobin, chloridesoluble mucoprotein, of heterogeneity of mucoprotein, v2-macroglobulin) helps in the evaluation of the severity of the inflammatory and macrophagel reactions in the paranecrotic zone. A useful intravital sign of the formation of a postinfarction scar is provided by the examination of collagen metabolites--oxyproline bound with collagen-like plasma protein and free serum oxyproline and urine excretion of total oxyproline. The obtained data can be used for the development of a rehabilitation programme, differentiated therapy in various groups of patients.
为制定心肌梗死后修复过程的活体标准，对62例在发病后不同时期死于心肌梗死的患者进行了临床、生化和形态学方面的对比研究。结果表明，一套实验室技术（对触珠蛋白、氯化物可溶性粘蛋白、粘蛋白异质性、v2-巨球蛋白的检测）有助于评估坏死旁区域炎症和巨噬细胞反应的严重程度。通过检测胶原代谢产物——与胶原样血浆蛋白结合的羟脯氨酸、游离血清羟脯氨酸以及总羟脯氨酸的尿排泄量，可为梗死灶后瘢痕形成提供有用的活体指标。所获数据可用于制定康复计划及对不同患者群体进行个体化治疗。
