Meyer T, Arndt R, Christophers E, Nindl I, Stockfleth E
Institute of Immunology, Pathology and Molecular Biology, Hamburg, Germany.
Cancer Detect Prev. 2001;25(6):533-47.
The frequent detection of HPV DNA in non-melanoma skin cancers was shown in several studies; however, the role of HPV in the development of these cancers remains speculative. We analyzed different skin tumors, normal skin, and hair follicles for HPV DNA using a PCR system designed to detect all HPV types known so far. HPV DNA was found in 93% of common warts, 69% of squamous cell carcinomas (SCC), 52% of basal cell carcinomas (BCC), 41% of actinic keratoses, 31% of extragenital Bowen's disease, 22% of keratoacanthomas, 16% of normal skin tissues and 47% of hair follicles. No individual HPV type predominated in any of the skin tumors. The number of HPV genomes in individual neoplasms (SCC and BCC) seems to be less than I per cancer cell. These results indicate that a direct role of HPV in skin cancerogenesis remains questionable. Possibly, mechanisms different from the activity of HPV oncoproteins in genital cancers are involved in skin neoplastic transformation.
多项研究表明，在非黑色素瘤皮肤癌中经常检测到HPV DNA；然而，HPV在这些癌症发生发展中的作用仍具有推测性。我们使用一种旨在检测目前已知所有HPV类型的PCR系统，对不同的皮肤肿瘤、正常皮肤和毛囊进行了HPV DNA分析。在93%的寻常疣、69%的鳞状细胞癌（SCC）、52%的基底细胞癌（BCC）、41%的光化性角化病、31%的外生殖器鲍温病、22%的角化棘皮瘤、16%的正常皮肤组织和47%的毛囊中发现了HPV DNA。在任何一种皮肤肿瘤中，均未发现某一特定HPV类型占主导地位。在单个肿瘤（SCC和BCC）中，HPV基因组数量似乎低于每个癌细胞1个。这些结果表明，HPV在皮肤癌发生中的直接作用仍值得怀疑。皮肤肿瘤性转化可能涉及与HPV癌蛋白在生殖器癌症中的活性不同的机制。
