Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
Dermatol Surg. 2013 Jan;39(1 Pt 1):1-23. doi: 10.1111/j.1524-4725.2012.02558.x. Epub 2012 Aug 28.
The role of human papillomavirus (HPV) in the induction and maintenance of cervical, anogenital, and some oropharyngeal carcinomas is well recognized, but its role in cutaneous squamous cell carcinoma (SCC) remains to be elucidated. HPV is thought to act as a possible cocarcinogen in the development of SCC.
To review the literature assessing the correlation between and possible causation of HPV and cutaneous SCC in immunocompetent and immunocompromised populations.
We reviewed HPV sampling and detection methods, epidemiologic studies examining HPV carriage in immunocompetent and immunosuppressed individuals, and evidence asserting an association between HPV and cutaneous SCC.
Although an abundant body of evidence points toward a link between HPV and cutaneous SCC, many studies indicate otherwise. Recent studies have focused on viral activity in addition to DNA presence.
The possibility exists that HPV may play a role in the induction but not maintenance of cutaneous SCC.
人乳头瘤病毒（HPV）在诱导和维持宫颈癌、肛门生殖器癌和一些口咽癌方面的作用已得到充分认识，但它在皮肤鳞状细胞癌（SCC）中的作用仍有待阐明。HPV 被认为是 SCC 发展过程中的一种可能的协同致癌原。
综述评估 HPV 与免疫功能正常和免疫功能低下人群的皮肤 SCC 之间的相关性及其可能的因果关系的文献。
我们回顾了 HPV 采样和检测方法、检查免疫功能正常和免疫抑制个体 HPV 携带情况的流行病学研究，以及 HPV 与皮肤 SCC 之间关联的证据。
尽管大量证据表明 HPV 与皮肤 SCC 之间存在关联，但许多研究表明并非如此。最近的研究侧重于病毒活性而不仅仅是 DNA 存在。
HPV 可能在诱导皮肤 SCC 但不在维持皮肤 SCC 方面发挥作用。
