蛋白质柔性与药物设计：如何击中一个移动的靶点。
Protein flexibility and drug design: how to hit a moving target.
作者信息
Carlson Heather A
机构信息
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065, USA.
出版信息
Curr Opin Chem Biol. 2002 Aug;6(4):447-52. doi: 10.1016/s1367-5931(02)00341-1.
Abstract
The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.
摘要
计算机辅助药物设计和数据库挖掘的最先进方法纳入了蛋白质的灵活性。这些技术不仅是获得正确结果所必需的；对于处理来自结构基因组学的不断增长的信息库而言，它们也是至关重要的。
Zotero 插件