Lather Amit, Rathee Pratibha, Gautam Manish Kumar, Sharma Kalicharan, Hooda Tanuj
Geeta Institute of Pharmacy, Geeta University, Panipat, Haryana, India.
MM College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana, India.
Curr Drug Discov Technol. 2025;22(4):e15701638336128. doi: 10.2174/0115701638336128250122223221.
Diabetes is a chronic metabolic disease of high levels of glucose in the blood and affecting 536.6 million people in the world between the age group of 20-79 with management spent of 11% of the total worldwide. Wound healing in diabetics is impaired due to many factors like high blood sugar, poor blood circulation, damaged blood vessels, diabetic neuropathy, decreased immune responses etc. The presently used synthetic drugs have high costs, a toxic nature, and are full of adverse effects drawing attention to the need to identify new and successful treatment approaches for diabetic wounds. drug screening methods of drug development made it easy to screen thousands of active constituents against a target specifically responsible for diabetes and wound healing. Thus the current review compiled the naturally available active compounds screened by docking from natural resources and has the potential to treat diabetic wound healing with their specificity and target-based mechanism. This information will be helpful for further screening of non-reported natural compounds having antidiabetic as well as wound healing potential.
糖尿病是一种慢性代谢疾病，其特征为血液中葡萄糖水平升高，全球20至79岁年龄段中有5.366亿人受其影响，治疗费用占全球总支出的11%。由于高血糖、血液循环不良、血管受损、糖尿病神经病变、免疫反应降低等多种因素，糖尿病患者的伤口愈合受到损害。目前使用的合成药物成本高、具有毒性且副作用大，因此需要寻找新的成功治疗方法来治疗糖尿病伤口。药物开发中的药物筛选方法使得针对专门负责糖尿病和伤口愈合的靶点筛选数千种活性成分变得容易。因此，本综述汇编了通过对接从自然资源中筛选出的天然活性化合物，这些化合物有可能凭借其特异性和基于靶点的机制治疗糖尿病伤口愈合。这些信息将有助于进一步筛选具有抗糖尿病和伤口愈合潜力的未报道天然化合物。
