Westerveld M, Loring D W
Dpt. of Neurosurgery; Yale University School of Medicine, New Haven, CT 06510, EE.UU.
Rev Neurol. 2002;34(9):865-70.
The Wada test for language and memory still plays an important role in evaluating the surgery performed on epileptic patients. The measures of the functional deficits carried out with the Wada test, associated with known brain lesions, aid in determining the lateralization of the onset of seizures and provide some estimate of the risk to memory after a temporal lobotomy.
A more refined procedure, based on the correlations with the titration from MRI, fMR and MR spectroscopy, will be needed. Moreover, using the Wada test it is possible to make long term forecasts about the cognitive outcome and about the control of seizures. When used together with other neurological, functional and psychometric evaluations, it becomes easier to select the patients with most chances of benefiting from surgical epilepsy treatment. Finally, the non invasive measures of brain functioning include fMR, which provides far more information than that obtained using the Wada test. However, it remains to be determined whether the procedure based on activation provides data of the same quality as those obtained by the Wada test, which can provide a more adequate reversible model of the effects of surgery on cognition.
. Ideally, as MRI and other imaging techniques progress, they will be able to offer complementary images, which will improve our capacity to forecast and prevent important post operative cognitive deficiencies.
瓦达试验用于评估语言和记忆功能，在癫痫患者手术评估中仍发挥着重要作用。通过瓦达试验测量与已知脑损伤相关的功能缺陷，有助于确定癫痫发作起始的侧别，并对颞叶切除术后的记忆风险提供一定评估。
需要一种基于与MRI、功能磁共振成像（fMRI）和磁共振波谱滴定相关性的更精细程序。此外，使用瓦达试验可以对认知结果和癫痫控制进行长期预测。当与其他神经学、功能和心理测量评估一起使用时，更容易选择最有可能从癫痫手术治疗中获益的患者。最后，脑功能的非侵入性测量包括功能磁共振成像，它提供的信息比瓦达试验获得的信息多得多。然而，基于激活的程序能否提供与瓦达试验相同质量的数据仍有待确定，瓦达试验可以提供手术对认知影响的更充分可逆模型。
理想情况下，随着MRI和其他成像技术的进步，它们将能够提供互补图像，这将提高我们预测和预防重要术后认知缺陷的能力。
