在鸡α-珠蛋白基因簇上游存在一段在红细胞和非红细胞中甲基化状态不同的CpG二核苷酸序列。 - Suppr

A block of CpG dinucleotides that are differentially methylated in erythroid and nonerythroid cells is located upstream of the cluster of chicken alpha-globin genes.

作者信息

Yudinkova E S, Razin S V

机构信息

Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 117334 Russia.

出版信息

Dokl Biochem Biophys. 2002 May-Jun;384:179-80. doi: 10.1023/a:1016084500746.

DOI:10.1023/a:1016084500746

PMID:12134517

Abstract

摘要

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A block of CpG dinucleotides that are differentially methylated in erythroid and nonerythroid cells is located upstream of the cluster of chicken alpha-globin genes.

Dokl Biochem Biophys. 2002 May-Jun;384:179-80. doi: 10.1023/a:1016084500746.

Extensive methylation of a part of the CpG island located 3.0-4.5 kbp upstream to the chicken alpha-globin gene cluster may contribute to silencing the globin genes in non-erythroid cells.

J Mol Biol. 2000 Jun 16;299(4):845-52. doi: 10.1006/jmbi.2000.3775.

A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain.

Mol Cell Biol. 2006 Mar;26(5):1589-97. doi: 10.1128/MCB.26.5.1589-1597.2006.

The CpG island of chicken alpha-globin genes contains no signals sufficient for the maintenance of its nonmethylated state in transgenic mouse genome.

Dokl Biochem Biophys. 2004 May-Jun;396:143-5. doi: 10.1023/b:dobi.0000033513.97299.bf.

CpG islands from the alpha-globin gene cluster increase gene expression in an integration-dependent manner.

Mol Cell Biol. 1997 Oct;17(10):5856-66. doi: 10.1128/MCB.17.10.5856.

Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain.

Mol Gen Genet. 1994 Mar;242(6):649-52. doi: 10.1007/BF00283418.

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13724-9. doi: 10.1073/pnas.94.25.13724.

Characteristic of the silencer located in the CpG-rich region upstream of the cluster of chicken alpha-globin genes.

Dokl Biochem Biophys. 2004 Sep-Oct;398:307-9. doi: 10.1023/b:dobi.0000046645.28603.7e.

CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes.

Mol Cell Biol. 2007 Jul;27(13):5047-54. doi: 10.1128/MCB.02234-06. Epub 2007 Apr 23.

An origin of bidirectional DNA replication is located within a CpG island at the 3" end of the chicken lysozyme gene.

Nucleic Acids Res. 1999 Aug 1;27(15):3009-17. doi: 10.1093/nar/27.15.3009.

本文引用的文献

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A block of CpG dinucleotides that are differentially methylated in erythroid and nonerythroid cells is located upstream of the cluster of chicken alpha-globin genes.

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A block of CpG dinucleotides that are differentially methylated in erythroid and nonerythroid cells is located upstream of the cluster of chicken alpha-globin genes.

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