Weiss A, Cedar H
Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel.
Genes Cells. 1997 Aug;2(8):481-6. doi: 10.1046/j.1365-2443.1997.1390337.x.
The somatic genomic methylation pattern which plays a role in the suppression of basal gene activity is established anew in each generation through developmentally regulated de novo and demethylation steps. Demethylation appears to be carried out by a nucleotide exchange reaction which may involve RNA molecules, and is directed to specific loci in the genome through interactions between cis acting elements and trans acting factors.
