Kalandadze A G, Bushara S A, Vassetzky Y S, Razin S V
Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow.
Biochem Biophys Res Commun. 1990 Apr 16;168(1):9-15. doi: 10.1016/0006-291x(90)91667-h.
The permanent sites of DNA attachment to the nuclear matrix in the domain of chicken alpha-globin genes originally found in erythrocyte nuclei have also been shown to exist in sperm and cultured fibroblast cells. A primary structure of a 1.7 kb fragment located in 5'-upstream region of chicken alpha-globin gene domain and containing both replication origin and permanent nuclear matrix attachment site has been determined. It was found to possess homologies with papovaviral replication origins and contain short internal repeats and GC-rich motifs.
最初在红细胞核中发现的鸡α-珠蛋白基因区域内与核基质相连的DNA永久位点，在精子和培养的成纤维细胞中也已被证明存在。位于鸡α-珠蛋白基因区域5'上游区域、包含复制起点和永久性核基质附着位点的一个1.7 kb片段的一级结构已被确定。发现它与乳头多瘤空泡病毒复制起点具有同源性，并含有短的内部重复序列和富含GC的基序。
