Mitsuyama Y, Thompson L R, Yuki I, Tanemori H
Folia Psychiatr Neurol Jpn. 1975;29(3):251-61. doi: 10.1111/j.1440-1819.1975.tb02342.x.
A case of chronic meningoencephalomyelitis in a 48-year-old housewife is presented. The onset was characterized by spastic paralysis of the lower extremities. The course was progressive with repeated remissions and exacerbations, and the patient died approximately seven years after the onset of disease. Laboratory tests showed slightly increased cell count in the spinal fluid, accelerated sedimentation rate, positive CRP and RA, and increased ASLO and gamma globulin levels. Neuropathologic examination revealed such changes as perivascular cellular infiltration, glial nodules, poorly demarcated demyelination and recent necrosis in the spinal cord and basal ganglia. Only mild inflammatory findings were noted in the telencephalon and brain stem. The clinico-pathologic findings in this case supported a diagnosis of chronic meningoencephalomyelitis which could not be classified as any known type of encephalomyelitis.
本文报告了一例48岁家庭主妇患慢性脑膜脑脊髓炎的病例。起病时以下肢痉挛性瘫痪为特征。病程呈进行性，有反复缓解和加重，患者在疾病发作约七年后死亡。实验室检查显示脑脊液细胞计数略有增加、血沉加快、CRP和类风湿因子阳性、抗链球菌溶血素O及γ球蛋白水平升高。神经病理学检查发现脊髓和基底节有血管周围细胞浸润、胶质结节、界限不清的脱髓鞘及近期坏死等变化。大脑和脑干仅见轻度炎症表现。该病例的临床病理结果支持慢性脑膜脑脊髓炎的诊断，且无法归类为任何已知类型的脑脊髓炎。
