Jiang Fan
Institute of Physics, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1277-81. doi: 10.1107/s090744490200971x. Epub 2002 Jul 20.
An alternative formulation of direct methods for phase refinement using the sign probability originally introduced for breaking the phase ambiguity intrinsic in single isomorphous replacement or single-wavelength anomalous diffraction data has been proposed. This formulation can incorporate known phase information through constrained phase refinement. This formulation was tested by application to the phase-extension problem using experimental data. The results showed that this formulation was valid and promising for designing better methods for phase extension.
有人提出了一种直接方法的替代公式，用于使用最初为解决单同晶置换或单波长反常衍射数据中固有的相位模糊性而引入的符号概率进行相位细化。该公式可以通过约束相位细化纳入已知的相位信息。通过使用实验数据应用于相位扩展问题对该公式进行了测试。结果表明，该公式对于设计更好的相位扩展方法是有效的且有前景的。
