Matsuyama T, Hoffman W H, Dunbar J C, Foà N L, Foà P P
Horm Metab Res. 1975 Nov;7(6):452-6. doi: 10.1055/s-0028-1093702.
Pancreatic glucagon (PG) and other glucagon-like immunoreactive materials (GLI) were measured in the plasma of normal and of newly diagnosed untreated diabetic children, using an antiglucagon serum (AGS) highly specific for pancreatic glucagon (AGS 18) and an AGS which crossreacts with extracts of intestinal mucosa (AGS 10). Gut GLI was considered to be the difference between "total" GLI (AGS 10) and PG (AGS 18). Glucose and immunoreactive insulin (IRI) were also measured. PG, total GLI and gut GLI were significantly elevated in children with severe insulin insufficiency and were reduced to normal by insulin treatment, even though a significant fasting hyperglycemia was still present. In three diabetic children who had high initial plasma IRI levels the three glucagon fractions were normal. We conclude that insulin insufficiency is characterized not only by high plasma levels of PG as previously reported, but also of gut GLI. These abnormalities can be corrected by the administration of insulin.
使用对胰高血糖素具有高度特异性的抗胰高血糖素血清（AGS 18）和与肠黏膜提取物发生交叉反应的抗胰高血糖素血清（AGS 10），测定了正常儿童和新诊断未经治疗的糖尿病儿童血浆中的胰高血糖素（PG）及其他胰高血糖素样免疫反应性物质（GLI）。肠道GLI被认为是“总”GLI（AGS 10）与PG（AGS 18）之间的差值。同时还测定了血糖和免疫反应性胰岛素（IRI）。在严重胰岛素不足的儿童中，PG、总GLI和肠道GLI显著升高，并且通过胰岛素治疗降至正常水平，尽管仍存在显著的空腹高血糖。在三名初始血浆IRI水平较高的糖尿病儿童中，三种胰高血糖素组分均正常。我们得出结论，胰岛素不足不仅如先前报道的那样以血浆PG水平升高为特征，而且还以肠道GLI水平升高为特征。这些异常情况可通过给予胰岛素得到纠正。
