Grossman Robert, Buchsbaum Monte S, Yehuda Rachel
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Psychiatr Clin North Am. 2002 Jun;25(2):317-40, vi. doi: 10.1016/s0193-953x(01)00011-9.
The authors review some of the advances that have been made in understanding the structural, biochemical, and functional neuroanatomy of post-traumatic stress disorder (PTSD). First, the authors review the primary brain regions that had been hypothesized a priori, from the phenomenology and neurobiology of PTSD, to be implicated in the pathophysiology. Next, they review findings from neuroimaging studies of these brain regions in PTSD, and explain the various experimental methods and imaging technologies used in these studies. A broader perspective, including a discussion of additional brain areas that may be involved in PTSD, is synthesized. The authors conclude with a rationale and approach for studies testing sharply defined hypotheses and those using multidisciplinary strategies that integrate neuroimaging data with other cognitive, biologic, and genetic tools to study this complex disorder.
作者回顾了在理解创伤后应激障碍（PTSD）的结构、生化和功能性神经解剖学方面取得的一些进展。首先，作者从PTSD的现象学和神经生物学出发，回顾了先验假设的主要脑区，这些脑区被认为与病理生理学有关。接下来，他们回顾了PTSD患者这些脑区的神经影像学研究结果，并解释了这些研究中使用的各种实验方法和成像技术。综合了更广泛的观点，包括对可能与PTSD有关的其他脑区的讨论。作者最后提出了研究的基本原理和方法，这些研究测试明确界定的假设，并采用多学科策略，将神经影像学数据与其他认知、生物学和遗传学工具相结合，以研究这种复杂的疾病。
