Niwano Shinichi
Department of Internal Medicine, Kitasato University School of Medicine.
Nihon Rinsho. 2002 Jul;60(7):1308-16.
The electrical remodeling in atrial fibrillation is defined as the shortening of the atrial effective refractoriness, the loss of its late dependency and the slowing of conduction velocity caused by rapid excitation of the atrial muscle. Although, this phenomenon may play an important role in promoting the appearance of the reentrant atrial fibrillation by shortening the wavelength, the clinical aim and importance of controlling the electrical remodeling are still unclear. Ca channel or Na channel blockers may reduce the electrical remodeling in relatively short-term by preventing the elevation of intracellular Ca concentration, though, the long-term effect is unknown.
心房颤动中的电重构被定义为心房有效不应期缩短、其晚期依赖性丧失以及心房肌快速兴奋导致的传导速度减慢。尽管这种现象可能通过缩短波长在促进折返性心房颤动的出现中起重要作用，但控制电重构的临床目的和重要性仍不明确。钙通道或钠通道阻滞剂可能通过防止细胞内钙浓度升高在相对短期内减少电重构，不过，其长期效果尚不清楚。
