Dobrev Dobromir
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany.
Herz. 2006 Apr;31(2):108-12; quiz 142-3. doi: 10.1007/s00059-006-2787-9.
Electrical remodeling refers to any change in electrical function that promotes atrial fibrillation (AF). A key advance in understanding the mechanisms of AF has been the identification of ion channels, gap junctions and regulators of intracellular Ca(2+) homeostasis as the molecular determinants of abnormal atrial electrical activity, and how these are modified in AF. This review focuses on the cellular and molecular basis of altered electrical properties of the atria in AF, with the goal of providing new insights into the potential molecular mechanisms and the identification of putative targets for antiarrhythmic therapy.
电重构是指促进心房颤动（AF）的任何电功能变化。在理解房颤机制方面的一项关键进展是，确定离子通道、缝隙连接和细胞内Ca(2+) 稳态调节因子是心房电活动异常的分子决定因素，以及它们在房颤中是如何被改变的。本综述重点关注房颤时心房电特性改变的细胞和分子基础，旨在为潜在的分子机制提供新见解，并确定抗心律失常治疗的假定靶点。
