[新霉素B的仿生类似物的合成]
[Synthesis of biomimetic analogs of neomycin B].
作者信息
Nishizono Naozumi
机构信息
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
出版信息
Yakugaku Zasshi. 2002 Jul;122(7):465-9. doi: 10.1248/yakushi.122.465.
PMID:12136642
Abstract
Neomycin B has been found to block the binding of HIV-1 Rev protein to its viral RNA recognition site, thereby inhibiting the production of the virus. This paper describes the synthesis of analogues of neomycin B, which are potential anti-HIV compounds designed as inhibitors of Rev/RRE binding.
摘要
已发现新霉素B可阻断HIV-1 Rev蛋白与其病毒RNA识别位点的结合，从而抑制病毒的产生。本文描述了新霉素B类似物的合成，这些类似物是设计用于抑制Rev/RRE结合的潜在抗HIV化合物。
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