日本与美国膝关节和手部影像学骨关节炎患病率的比较。

Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States.

作者信息

Yoshida Shoji, Aoyagi Kiyoshi, Felson David T, Aliabadi Piran, Shindo Hiroyuki, Takemoto Tai-Ichiro

机构信息

Department of Orthopedic Surgery, Nagasaki University School of Medicine, Japan.

出版信息

J Rheumatol. 2002 Jul;29(7):1454-8.

PMID:12136905

Abstract

OBJECTIVE

There is no direct international comparison of the prevalence of osteoarthritis (OA) between Japanese and Caucasians. We compared the prevalence of radiographic knee and hand OA between women in Hizen-Oshima, Japan, and in Framingham, Massachusetts, USA.

METHODS

A population based cross sectional study among 358 women in Japan and 815 women in the USA aged 63 years or older for knee joints, and 157 women in Japan and 655 women in the USA aged 71 years or older for hands. Radiographs were obtained of knees and hands, and were graded according to the Kellgren-Lawrence (K-L) criteria. Definite OA was defined as K-L grade 2 or higher, present in at least one joint of a given group. A person was defined as having OA or not in a given joint group, and we used logistic regression with the US group as referent to determine the prevalence odds ratio of OA among Japanese.

RESULTS

The age adjusted prevalence of knee OA in Japanese women was higher than in Caucasians (OR 1.96, 95% CI 1.50-2.56), while the prevalence of hand OA other than distal interphalangeal joint in Japanese was lower than in Caucasians (OR for proximal interphalangeal joint 0.66, 95% CI 0.46-0.93; OR for metacarpophalangeal joint 0.62, 95% CI 0.42-0.90), especially base of thumb OA (OR 0.15, 95% CI 0.11-0.22).

CONCLUSION

These findings suggest site-specific differences in the prevalence of OA that may be attributed to genetic and/or environmental factors.

摘要

目的

目前尚无日本人和高加索人骨关节炎（OA）患病率的直接国际比较。我们比较了日本肥前大岛和美国马萨诸塞州弗雷明汉63岁及以上女性膝关节和手部X线骨关节炎的患病率。

方法

对日本的358名女性和美国的815名63岁及以上女性进行膝关节的基于人群的横断面研究，对日本的157名女性和美国的655名71岁及以上女性进行手部的研究。获取膝关节和手部的X线片，并根据凯尔格伦-劳伦斯（K-L）标准进行分级。确诊的OA定义为K-L 2级或更高，存在于给定组的至少一个关节中。确定一个人在给定关节组中是否患有OA，我们以美国组为参照，使用逻辑回归来确定日本人中OA的患病率比值比。

结果

日本女性膝关节OA的年龄调整患病率高于白种人（OR 1.96，95%CI 1.50 - 2.56），而日本除远端指间关节外的手部OA患病率低于白种人（近端指间关节的OR为0.66，95%CI 0.46 - 0.93；掌指关节的OR为0.62，95%CI 0.42 - 0.90），尤其是拇指基部OA（OR 0.15，95%CI 0.11 - 0.22）。