Englund M, Haugen I K, Guermazi A, Roemer F W, Niu J, Neogi T, Aliabadi P, Felson D T
Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, USA.
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Osteoarthritis Cartilage. 2016 Feb;24(2):270-3. doi: 10.1016/j.joca.2015.08.005. Epub 2015 Aug 28.
The etiology of degenerative meniscus tear is unclear but could be related to a generalized osteoarthritic disease process. We studied whether radiographic hand osteoarthritis (OA) is associated with meniscus damage.
We examined 974 persons aged 50-90 years drawn via census tract data and random-digit dialing from Framingham, Massachusetts, United States. One reader assessed bilateral hand radiographs (30 joints) and another read frontal knee radiographs, all according to the Kellgren-Lawrence (KL) scale. A third reader assessed right knee 1.5-T magnetic resonance imaging (MRI) scans for meniscus damage. We calculated the prevalence of medial and/or lateral meniscus damage in those with one to two and three or more finger joints with radiographic OA (KL grade ≥2) compared to those without radiographic hand OA with adjustment for age, sex, and body mass index. We also evaluated the above association in persons without evidence of radiographic OA (KL grade 0) in their knee (n = 748).
The prevalence of meniscus damage in the knee of subjects with no, one to two, and three or more finger joints with OA was 24.9%, 31.7%, and 47.2%, respectively. The adjusted prevalence ratio (PR) of having meniscus damage was significantly increased in those who had three or more finger joints with OA (1.40 [95% confidence interval (CI) 1.11-1.77]). The estimate remained similar in persons without evidence of radiographic OA in their knee (PR, 1.42 [95% CI 1.03-1.97]). The association was more robust for medial meniscus damage.
Results suggest a common non-age related etiologic pathway for both radiographic hand OA and meniscus damage.
退行性半月板撕裂的病因尚不清楚，但可能与全身性骨关节炎疾病进程有关。我们研究了手部X线骨关节炎（OA）是否与半月板损伤相关。
我们通过人口普查区数据和随机数字拨号，从美国马萨诸塞州弗雷明汉选取了974名年龄在50至90岁之间的人。一名阅片者根据Kellgren-Lawrence（KL）量表评估双侧手部X线片（30个关节），另一名阅片者阅读膝关节正位X线片。第三名阅片者评估右膝1.5-T磁共振成像（MRI）扫描以判断半月板损伤情况。我们计算了与无手部X线OA的人相比，有一至两个以及三个或更多手指关节出现X线OA（KL分级≥2）的人内侧和/或外侧半月板损伤的患病率，并对年龄、性别和体重指数进行了调整。我们还在膝关节无X线OA证据（KL分级0）的人群（n = 748）中评估了上述关联。
无OA、有一至两个手指关节OA以及有三个或更多手指关节OA的受试者膝关节半月板损伤的患病率分别为24.9%、31.7%和47.2%。有三个或更多手指关节OA的人发生半月板损伤的校正患病率比（PR）显著增加（1.40 [95%置信区间（CI）1.11 - 1.77]）。在膝关节无X线OA证据的人群中，该估计值相似（PR，1.42 [95% CI 1.03 - 1.97]）。这种关联在内侧半月板损伤中更为显著。
结果表明手部X线OA和半月板损伤存在共同的非年龄相关病因途径。
