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针灸及电针治疗类风湿关节炎

Acupuncture and electroacupuncture for the treatment of RA.

作者信息

Casimiro L, Brosseau L, Milne S, Robinson V, Wells G, Tugwell P

机构信息

School of Rehabilitation Sciences, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada, K1H 8M5.

出版信息

Cochrane Database Syst Rev. 2002(3):CD003788. doi: 10.1002/14651858.CD003788.


DOI:10.1002/14651858.CD003788
PMID:12137715
Abstract

BACKGROUND: Acupuncture has been used by rehabilitation specialists as an adjunct therapy for the symptomatic treatment of rheumatoid arthritis (RA). Acupuncture is a traditional Chinese medicine where thin needles are inserted in specific documented points believed to represent concentration of body energies. In some cases a small electrical impulse is added to the needles. Once the needles are inserted in some of the appropriate points, endorphins, morphine-like substances, have been shown to be released in the patient's system, thus inducing local or generalised analgesia. OBJECTIVES: To evaluate the effects of acupuncture or electroacupuncture on the objective and subjective measures of disease activity in patients with RA. SEARCH STRATEGY: A comprehensive search was done up to September 2001 with MEDLINE, EMBASE, PEDro, Current Contents, Sports Discus and CINAHL. The Cochrane Field of Rehabilitation and Related Therapies and the Cochrane Musculoskeletal Review Group were also contacted for a search of their specialized registers. Handsearching was conducted on all retrieved papers and content experts were contacted to identify additional studies. SELECTION CRITERIA: Comparative controlled studies, such as randomized controlled trials and control clinical trials in patients with RA were eligible. No language restrictions were applied. Abstracts were accepted. DATA COLLECTION AND ANALYSIS: Two independent reviewers identified potential articles from the literature search. These reviewers extracted data using pre-defined extraction forms. Consensus was reached on all the extracted data. Quality was assessed by two reviewers using a five (5) point validated tool that measured the quality of randomization, double-blinding and description of withdrawals. MAIN RESULTS: Two studies (n=84) met the inclusion criteria. One used acupuncture (David 1999) while the other used electroacupuncture (Man 1974). In the first study using acupuncture, no significant difference was found between groups for to erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the visual analogue scale for pain (VAS P), the visual analogue scale for patient's global assessment (VAS G), the number of swollen joints, the number of tender joints, to the general health questionnaire (GHQ), the score on the modified disease activity scale (DAS) or in the decrease in analgesic intake. In the second study, using electroacupuncture, a significant decrease in knee pain was reported in the experimental group, 24 hours post treatment, when compared to the placebo group (weighted mean difference of -2.0 with 95% CI -3.6,-4.0). REVIEWER'S CONCLUSIONS: Although the results of the Man 1974 study show that electroacupuncture may be beneficial to reduce symptomatic knee pain in patients with RA 24 hours post treatment, the reviewers concluded that the poor quality of the trial, including the small sample size proclude its recommendation. The reviewers further conclude that acupuncture has no effect on ESR, CRP, pain, patient's global assessment, number of swollen joints, number of tender joints, general health, disease activity and reduction of analgesics. These conclusions are limited by methodological considerations such as the type of acupuncture (acupuncture vs electroacupuncture), the site of intervention, the low number of clinical trials and the small sample size of the included studies.

摘要

背景:康复专家已将针灸作为类风湿性关节炎(RA)症状治疗的辅助疗法。针灸是一种传统中医疗法,将细针插入特定的、有文献记载的穴位,这些穴位被认为是人体能量的聚集点。在某些情况下,会给针施加微小的电脉冲。一旦针插入一些合适的穴位,内啡肽,即类似吗啡的物质,已被证明会在患者体内释放,从而产生局部或全身性镇痛效果。 目的:评估针灸或电针疗法对类风湿性关节炎患者疾病活动的客观和主观指标的影响。 检索策略:截至2001年9月,使用MEDLINE、EMBASE、PEDro、《现刊目次》、《体育文献数据库》和CINAHL进行了全面检索。还联系了Cochrane康复及相关疗法领域和Cochrane肌肉骨骼综述小组,以检索其专业登记册。对所有检索到的论文进行了手工检索,并联系了内容专家以识别其他研究。 入选标准:符合条件的为比较对照研究,如类风湿性关节炎患者的随机对照试验和对照临床试验。不设语言限制。接受摘要。 数据收集与分析:两名独立评审员从文献检索中识别潜在文章。这些评审员使用预定义的提取表格提取数据。对所有提取的数据达成了共识。由两名评审员使用一个经过验证的五分制工具评估质量,该工具衡量随机化、双盲和撤药描述的质量。 主要结果:两项研究(n = 84)符合纳入标准。一项使用针灸(David 1999),另一项使用电针(Man 1974)。在第一项使用针灸的研究中,两组在红细胞沉降率(ESR)、C反应蛋白(CRP)、疼痛视觉模拟量表(VAS P)、患者整体评估视觉模拟量表(VAS G)、肿胀关节数、压痛关节数、一般健康问卷(GHQ)、改良疾病活动量表(DAS)评分或镇痛药物摄入量减少方面均未发现显著差异。在第二项使用电针的研究中,与安慰剂组相比,治疗后24小时,试验组报告膝关节疼痛显著减轻(加权平均差为 -2.0,95%置信区间为 -3.6,-4.0)。 评审员结论:尽管Man 1974研究的结果表明电针疗法可能有助于在治疗后24小时减轻类风湿性关节炎患者的膝关节疼痛症状,但评审员得出结论,该试验质量较差,包括样本量小,不建议采用。评审员进一步得出结论,针灸对ESR、CRP、疼痛、患者整体评估、肿胀关节数、压痛关节数、一般健康状况、疾病活动度和镇痛药物减少没有影响。这些结论受到方法学因素的限制,如针灸类型(针灸与电针)、干预部位、临床试验数量少以及纳入研究的样本量小。

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引用本文的文献

[1]
Acupuncture for chronic uncomplicated musculoskeletal pain associated with the spine: A systematic review protocol.

Medicine (Baltimore). 2019-1

[2]
A pilot study of acupuncture as adjunctive treatment of rheumatoid arthritis.

Clin Rheumatol. 2008-5

[3]
Electro-acupuncture at acupoint ST36 reduces inflammation and regulates immune activity in Collagen-Induced Arthritic Mice.

Evid Based Complement Alternat Med. 2006-8-18

[4]
EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).

Ann Rheum Dis. 2007-1

[5]
Children in reviews: methodological issues in child-relevant evidence syntheses.

BMC Pediatr. 2005-9-21

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