Ishiguro Chizuru, Yaguchi Yutaka, Funabiki Kazuhiko, Horikoshi Satoshi, Shirato Isao, Tomino Yasuhiko
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Nephron. 2002 Aug;91(4):755-8. doi: 10.1159/000065043.
Recently, the authors reported that the ratio of serum IgA to C3 (serum IgA/C3 ratio) is a good marker to distinguish patients with IgA nephropathy from non-IgA nephropathy patients together with serum IgA levels using an international reference preparation (IFCC/CRM470). In this study, the authors investigated whether the serum IgA/C3 ratio might be an indicator of prognostic grading in patients with IgA nephropathy. Two hundred and thirteen patients with IgA nephropathy and 96 other glomerular diseases including diffuse or focal mesangial proliferative glomerulonephritis without mesangial IgA deposition (non-IgA PGN), membranous nephropathy and thin basement membrane syndrome were examined. The levels of serum IgA and C3 in these patients were adjusted by the specified formula to those using international standard serum (IFCC/CRM470) in this study. The results of this study showed the highest levels of IgA/C3 ratio in patients with IgA nephropathy. The serum IgA/C3 ratio appears to gradually increase according to the prognostic grading of this disease. Therefore, measurement of the serum IgA/C3 ratio may be useful for prediction of diagnosis and prognostic grading in patients with IgA nephropathy.
最近，作者报告称，血清IgA与C3的比值（血清IgA/C3比值）是一种很好的标志物，可与血清IgA水平一起，使用国际参考制剂（IFCC/CRM470）区分IgA肾病患者与非IgA肾病患者。在本研究中，作者调查了血清IgA/C3比值是否可能是IgA肾病患者预后分级的一个指标。对213例IgA肾病患者和96例其他肾小球疾病患者进行了检查，其他肾小球疾病包括无系膜IgA沉积的弥漫性或局灶性系膜增生性肾小球肾炎（非IgA PGN）、膜性肾病和薄基底膜综合征。在本研究中，通过特定公式将这些患者的血清IgA和C3水平调整为使用国际标准血清（IFCC/CRM470）时的水平。本研究结果显示，IgA肾病患者的IgA/C3比值最高。血清IgA/C3比值似乎会根据该疾病的预后分级而逐渐升高。因此，测定血清IgA/C3比值可能有助于预测IgA肾病患者的诊断和预后分级。
