Zhu Shuangshuang, Li Yongqiang, Zhou Shulu, Wei Qingzhu, Deng Kangping, Wang Xiaohong, Li Bin, Liu Jianghuan, Liu Xinyu, Zhang Ying, Shao Xiaofei, Liu Aiqun, Wu Bifang, Zhao Zhihong, Xu Xiaomeng, Lin Hanfei, Liu Qin, Li Jiamin, Wang Honglei, Zhou Qin, Zhu Chaoya, Lv Daoyuan, Xia Yue, Zou Hequn
Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2015 Dec;35(12):1683-8.
To investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients.
Sixty-six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee's classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy.
Patients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy.
In the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgA nephropathy.
探讨血清IgA/C3比值在IgA肾病诊断中的价值，并探讨其与患者临床病理特征的关系。
采用CRM470校准的标准化免疫比浊法检测66例IgA肾病患者、111例其他肾小球疾病患者和40例无肾脏疾病的健康对照者的血清IgA和C3水平，并计算IgA/C3比值。根据牛津和李氏分类标准，分析IgA肾病患者肾活检样本的病理分级。采用ROC曲线评估血清IgA和IgA/C3比值预测IgA肾病的价值。
IgA肾病患者血清IgA/C3比值高于其他肾小球疾病患者和对照者，ROC曲线下面积为0.776。未发现IgA肾病患者血清IgA/C3比值升高与肾活检样本的病理分级显著相关。
在无肾活检结果的情况下，血清IgA/C3比值有助于IgA肾病的诊断。
