Kojima Kentaro, Yokoi Norihiko, Nakamura Yo, Takada Yoko, Sato Hiroko, Komuro Aoi, Sugita Jiro, Kinoshita Shigeru
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto 602-0841, Japan.
Nippon Ganka Gakkai Zasshi. 2002 Jun;106(6):360-4.
Punctal occlusion using a silicone plug is one way of treating tear-deficient dry eye and it has been reported to be effective. We studied the outcome of punctal plug occlusion therapy for severe dry eye syndrome at our dry eye clinic.
Subjects were 76 eyes of 51 patients [6 eyes of 5 males, 70 eyes of 46 females, mean age: 58.6 +/- 13.4 (mean +/- standard deviation), 49 eyes of 30 patients with Sjögren's syndrome, 27 eyes of 21 patients without Sjögren's syndrome] with severe tear-deficient dry eye who underwent punctal occlusion using a silicone plug (Punctal plug, FCI Co. Ltd, France) during the period of Nov. 1996 to Mar. 2000 at our dry eye clinic. They were under observation for 632 +/- 405 days (mean +/- standard deviation). We studied if there is difference in tolerance between the sizes of punctal plug, compared epithelial damage before and after plug insertion, and studied relief in symptoms using self-assessment.
In tolerance of punctal plugs, 55.9% of all plugs were lost during our follow up, but there was no difference in time to loss between the sizes. Epithelial damage was reduced (p < 0.001). Dryness was the most reduced symptom: 26 patients (79%) got better, and only epiphora was increased, with 12 patients (36%) complaining slightly.
Punctal plug occlusion therapy for tear-deficient dry eye is conclusively very effective.
使用硅胶栓进行泪点封闭是治疗泪液缺乏型干眼症的一种方法，据报道其具有有效性。我们在干眼症门诊研究了泪点栓封闭疗法治疗严重干眼症综合征的效果。
研究对象为1996年11月至2000年3月期间在我们干眼症门诊接受硅胶栓（法国FCI有限公司生产的泪点栓）泪点封闭治疗的51例患者的76只眼[5例男性的6只眼，46例女性的70只眼，平均年龄：58.6±13.4（平均值±标准差），30例干燥综合征患者的49只眼，21例非干燥综合征患者的27只眼]，这些患者患有严重的泪液缺乏型干眼症。他们接受了632±405天（平均值±标准差）的观察。我们研究了泪点栓大小在耐受性方面是否存在差异，比较了栓插入前后的上皮损伤情况，并通过自我评估研究了症状缓解情况。
在泪点栓的耐受性方面，在我们的随访期间，所有栓中有55.9%丢失，但不同大小的栓在丢失时间上没有差异。上皮损伤有所减轻（p<0.001）。干燥是减轻最明显的症状：26例患者（79%）病情好转，只有溢泪有所增加，12例患者（36%）略有抱怨。
泪点栓封闭疗法治疗泪液缺乏型干眼症确实非常有效。
