Shi Shuai, Chen Wei, Zhang Xin, Ma Hui-xiang, Sun Li
School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China.
Zhonghua Yan Ke Za Zhi. 2013 Feb;49(2):151-4.
To evaluate the efficacy of silicone punctual plug for treating aqueous tear deficiency dry eye patients.
Prospective consecutive cases study. Silicone punctal plugs (France Chirurgie Instrumentation) were inserted into lower canaliculus in 65 tear deficiency dry eye patients (65 eyes). The clinical data collected included sex and age of the patients, frequency of lubricant use, the Ocular Surface Disease Index (OSDI) scores, slit lamp microscope examination, Schirmer I test (SIT) (with anesthesia), tear break-up time (TBUT), and ocular surface staining with fluoresce in sodium. All examinations were recorded at baseline, 6 weeks and 6 months after punctal occlusion.
There were 41 women and 24 men in this study, and their average age was 41.77 years old. The dry eye symptoms improved in 57 (87.69%) of 65 eyes at 6 months follow-up. The frequency of lubricant use was significantly decreased in these eyes (χ(2) = 81.97, P < 0.01). More importantly, the symptoms disappeared in 25 (38.46%) eyes, which did not need lubricant any more. At baseline, 6 weeks and 6 months after punctal occlusion, OSDI mean score was 37.32 ± 2.41, 19.60 ± 8.07 and 18.17 ± 7.93, respectively (F = 344.10, P < 0.01); mean SIT result was (3.03 ± 0.75) mm, (6.66 ± 2.10) mm and (6.75 ± 2.16) mm, respectively (F = 169.59, P < 0.01); mean TBUT was (2.91 ± 0.76) s, (7.02 ± 2.39) s and (7.57 ± 2.38) s, respectively (F = 242.00, P < 0.01). Compared with the baseline data, hyperemia of conjunctiva grading and ocular surface staining scores were also improved significantly after plug insertion, and all of these differences were statistically significant. Foreign body sensation was the most common complication in our study (12 eyes, 18.46%). Epiphora (4 eyes, 6.15%), partial extrusion (3 eyes, 4.62%), and total extrusion (3 eyes, 4.62%) were the other complications encountered.
Silicone punctal plug insertion is a stable, effective and safety method for the treatment of tear deficiency dry eye.
评估硅胶泪点塞治疗水样泪液缺乏型干眼症患者的疗效。
前瞻性连续病例研究。将硅胶泪点塞（法国手术器械公司）插入65例泪液缺乏型干眼症患者（65只眼）的下泪小管。收集的临床资料包括患者的性别和年龄、润滑剂使用频率、眼表疾病指数（OSDI）评分、裂隙灯显微镜检查、Schirmer I试验（SIT）（表面麻醉下）、泪膜破裂时间（TBUT）以及荧光素钠眼表染色。所有检查在泪点封闭前、封闭后6周和6个月时记录。
本研究中女性41例，男性24例，平均年龄41.77岁。随访6个月时，65只眼中57只（87.69%）干眼症症状改善。这些眼中润滑剂使用频率显著降低（χ(2)=81.97，P<0.01）。更重要的是，25只眼（38.46%）症状消失，不再需要使用润滑剂。泪点封闭前、封闭后6周和6个月时，OSDI平均评分分别为37.32±2.41、19.60±8.07和18.17±7.93（F=344.10，P<0.01）；SIT平均结果分别为(3.03±0.75)mm、(
